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Pathology Navigator on Instagram: "Follow + Save + Share ✅ Goodpasture syndrome = lung + kidney red flag you must not miss 🫁🩸🩺 📌 Core mechanism • Type II hypersensitivity (antibody-mediated) 🎯 • IgG against type IV collagen (GBM + alveolar BM) 🧬 🚨 Classic presentation • Hemoptysis from pulmonary hemorrhage 🫁 • Rapidly progressive glomerulonephritis → rising creatinine 🧪 • Hematuria + red blood cell casts 🩸 ⭐ Most asked diagnostic clue • Linear IgG (± C3) on immunofluorescence along GBM
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Agammaglobulinemia is an uncommon inherited immunodeficiency condition marked by a deficiency or absence of mature B cells. Goodpasture syndrome is a rare autoimmune disorder wherein the body erroneously generates antibodies that target the lungs and kidneys. Granulomatosis with polyangiitis (GPA) is an infrequent vasculitis affecting small blood vessels. Leukocyte adhesion deficiency (LAD) is an immunodeficiency disorder that impacts both B and T cells. Pediatric Bruton Agammaglobulinemia is an
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