Background Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality with limited therapeutic options. Despite promising immunotherapy, response rates remain suboptimal. Tumour-associated ...

Background Chronic pancreatitis (CP) is a risk factor for pancreatic cancer, with inherited cases conferring a markedly increased risk. The underlying mechanisms driving malignant transformation by CP ...

This important study describes a deep learning framework that analyzes single-cell RNA data to identify a tumor-agnostic gene signature associated with brain metastases. The identified signature ...

Hello! Thank you for making this tool :)! I have two conditions and four Xenium samples (from different patients, total n=8) within each. My understanding from the CellChat documentation is that in ...

Introduction: Clonal hematopoiesis of indeterminate potential (CHIP) was recently shown to be an independent risk factor for immune checkpoint inhibitor (ICI)-associated myocarditis. However, the ...

Clonal hematopoiesis of indeterminate potential (CHIP) is a known risk factor for coronary artery disease, though its precise role in disease progression continues to emerge. This study leverages ...

Official support for free-threaded Python, and free-threaded improvements Python’s free-threaded build promises true parallelism for threads in Python programs by removing the Global Interpreter Lock ...

We integrated single-cell RNA sequencing (scRNA-seq) data from primary tumors and metastatic lesions with bulk tissue transcriptomes and plasma-derived exosomal RNA sequencing (RNA-seq).

Gaining insights into the complex pathways and key cell populations involved in immune dysregulation can aid the development of therapeutic approaches to treat polytrauma, which is associated with ...

A research team led by Professors Yixuan Wang and Shaorong Gao from the School of Life Sciences and Technology at Tongji University has made significant progress in understanding early human embryonic ...