Background Patients with heart failure (HF) frequently suffer from undetected declines in cardiorespiratory fitness (CRF), which significantly increases their risk of poor outcomes. However, current ...
Deep mutational scanning reveals pharmacologically relevant insights into TYK2 signaling and disease
This important paper presents a rigorous and comprehensive deep mutational analysis of the kinase TYK2, revealing how single amino acid substitutions influence protein abundance, signaling activity, ...
This breakdown of the best actor race weighs the strengths and vulnerabilities of each contender as SAG and BAFTA voting are underway. What does each one have going for them, and against them. For Him ...
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