Nature

A deep multiple instance learning framework improves microsatellite instability detection from tumor next generation sequencing

Microsatellite instability (MSI) is a critical phenotype of cancer genomes and an FDA-recognized biomarker that can guide treatment with immune checkpoint inhibitors. Previous work has demonstrated ...
Nature

Multiple-instance learning of somatic mutations for the classification of tumour type and the prediction of microsatellite status

Large-scale genomic data are well suited to analysis by deep learning algorithms. However, for many genomic datasets, labels are at the level of the sample rather than for individual genomic measures.