Only a few years ago, Tuesday’s announcement that a glove believed to be connected to the disappearance of Nancy Guthrie in Tucson, Arizona, had no match in a DNA database would have been a dead end.

Investigators in Arizona are hoping that DNA found in and around Nancy Guthrie's house in Tucson could lead them to a suspect — and the missing woman. Guthrie, the 84-year-old mother of Today show ...