A minimal set of genes that is necessary and sufficient for sustaining a functional cell can be delineated either by computational comparisons of microbial genomes or experimentally by knocking out ...

The expectation was that the evolution of this organism was subject to strong constraints because any mutation could lethally disrupt one or more cellular functions. In addition, its streamlined ...

The majority of patients in need of a hematopoietic-cell transplant do not have a matched related donor. Data are needed to inform the choice among various alternative donor-cell sources. In this ...

Despite the molecular heterogeneity of standard-risk acute myeloid leukemia (AML), treatment decisions are based on a limited number of molecular genetic markers and morphology-based assessment of ...