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The San Francisco 49ers battle the Arizona Cardinals in their home opener at Levi’s Stadium on Sunday, Sept. 21 at 1:25 p.m. PDT. The Niners are coming off consecutive road victories to open the season, including a 26-21 win in New Orleans with backup quarterback Mac Jones directing the offense.

Former Jaguars wide receiver Christian Kirk will make his first return to EverBank Stadium since the Jaguars traded him to the Texans last March. Kirk was a key piece of the offense for three years, and on Sunday he is the enemy for the first time.

San Francisco is a 2.5-point favorite in the latest Cardinals vs. 49ers odds from SportsLine consensus, while the over/under for total points scored is 44.5. The 49ers are -128 money line favorites (risk $128 to win $100),

Jaguars vs. Texans recent matchups. Over their last five meetings, Houston has tallied three wins versus Jacksonville. The Jaguars have a 4-1 record ATS in those games, while the

Seahawks or Saints? Here are score predictions for the Seahawks' Week 3 game vs. the Saints from Bob Condotta and other Seattle Times sports staff members.