A newly developed luciferase-based reporter can detect problems in protein translocation and disulfide bond formation in the endoplasmic reticulum (ER). Inspired by natural mechanisms found in ...

Imagine a breakthrough in cancer treatment where only malignant cells are targeted, sparing healthy host cells; or patients with abnormal protein synthesis are treated to produce a healthy protein.

A study on how aging impacts the brain in killifish has found that getting old selectively impairs the production of some key DNA- and RNA-binding proteins. And this change contributes to hallmarks of ...