ascopubs.org

Clinical Implementation of Expanded Solid Tumor Fusion Detection With Whole-Transcriptome Sequencing at an Academic Cancer Center

We validated a clinical bait-capture WTS assay using 78 solid tumor samples across diverse tissue types, including 59 with known fusions or oncogenic splice variants. Sensitivity was assessed against ...
ascopubs.org

Clinical utility of whole transcriptome sequencing for fusion detection in advanced solid tumors: SCRUM-Japan MONSTAR-SCREEN-2.

Early-onset cancer signature (EOCS): Pan-cancer molecular alterations with prognostic significance in early-onset (EOC) and late-onset (LOC) cancer. Pan-cancer KRAS atlas of 9,056 Chinese patients: ...
EurekAlert!

Long-Read Whole-Transcriptome Sequencing and Selective Gene Panel Profiling Enable Sensitive Detection of Fusion Oncogenes in Pediatric B-Cell Acute Lymphoblastic Leukemia (IMAGE)

Comparison of conventional B-cell acute lymphoblastic leukemia (B-ALL) fusion diagnostics (top) and Nanopore-based fusion detection (bottom). Current diagnostics involve multiple tests, whereas ...
News Medical

How single-cell sequencing is reshaping our understanding of cellular diversity

Single-cell sequencing is useful for a number of applications. For example, it can reveal cellular heterogeneity inside complex tissues, such as tumors. It can also provide information about how ...