Investigators led by Navdeep Chandel, Ph.D., the David W. Cugell, MD, Professor of Medicine in the Division of Pulmonary and Critical Care, have discovered how the metabolism of mitochondria supports ...

Scientists uncover a new “recipe” that shows how exhausted T cells can be reprogrammed to regain their ability to attack tumors.

A multi-institutional study has mapped the genetic circuitry that determines whether CD8 killer T cells become durable immune defenders or lapse into exhaustion, and has shown that disabling two ...

Scientists discovered key genetic factors that determine whether a T cell acts as a powerful disease fighter or enters an ineffective, exhausted state. Turning off two transcription factors allowed ...

Pre-wired ability in ‘resting’ T cells to remember past viral foes discovered, a promising breakthrough for targeted cancer therapies. A team of immunologists at the University of Massachusetts ...

CD8⁺ T cells are the frontline soldiers of the body against cancer, but their prolonged exposure to tumor antigens often leads to an exhausted state ...

Researchers at the Max Delbrück Center have found that a cellular housekeeping mechanism called autophagy plays a major role in ensuring that T stem cells undergo normal cell division. The findings, ...

By Hugo Francisco de Souza A novel CAR-T cell approach targets amyloid plaques in preclinical Alzheimer models, raising the ...