Cumulative evidence supports the idea that a gradient of Ran controls the mitotic spindle assembly. During mitosis, RCC1 associates with chromosomes, generating a gradient of RanGTP around chromosomes ...
Mechanistic model for MTOC maturation in GV oocytes. The MTOC (grey) activates near the oocyte cortex, which requires recruitment of CKAP5 and TACC3. After activation, MTOC migrates to the nuclear ...
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