Shane A. Fiorenza, Daniel G. Steckhahn,and Meredith D. Betterton (2021). European Physical Journal E 44,105. DOI: 10.1140/epje/s10189-021-00097-8. BioRxiv link ...

This important study introduces a new biology-informed strategy for deep learning models aiming to predict mutational effects in antibody sequences. It provides solid evidence that separating ...

Uncovering the molecular structures of proteins can help scientists elucidate biological functions of proteins and search for drug candidates for diseases. To better understand proteins, scientists ...

The people behind the original protein modeling tool Alphafold have now developed a newer version, Alphafold 3, which is changing the way that this fundamental technology works. Looking at the changes ...

A milestone report proposes a new technique for modeling molecular life with computers. The advance promises new insights into the fundamental biology of a cell, as well as faster and more precise ...

In physiological conditions, most proteins are coated with complex sugars via N- and O-glycosylation, which are mobile and dynamic, influencing how proteins interact with other molecules. The dynamic ...

HLA-Arena can be integrated in computational pipelines to support basic cancer research or to help inform physicians in preclinical settings. It can be used to perform structure-based selection of ...

Figure 1: Distribution of the % sequence identity between the known protein structures and proteins of Mycobaterium genitalium, modeled as in ref. 13 in February, 2000. The targets for structure ...

WEST LAFAYETTE, Ind. – Proteins are often called the working molecules of the human body. A typical body has more than 20,000 different types of proteins, each of which are involved in many functions ...