The expression of genes has to be very carefully controlled by cells; serious problems can arise when genes are expressed in the wrong places, at the wrong times, or at the wrong levels, for some ...

Long non-coding RNAs (lncRNA) are a type of RNA molecule that do not carry instructions to make proteins. Instead, they influence how other genes are expressed. There are tens of thousands of lncRNAs ...

Non-coding RNAs (ncRNAs) have emerged as critical regulators in tumour initiation, progression and metastasis. Far from being transcriptional noise, distinct classes of ncRNAs—including microRNAs, ...

Chinese Medical Journals Publishing House Co., Ltd. Pancreatic cancer, one of the leading causes of deaths, refers to the abnormal growth of cells in the pancreas. Only 10% of patients live more than ...

A research team from National Taiwan University, Academia Sinica, and National Taiwan University Hospital has uncovered a critical connection between a unique RNA molecule and human aging, including ...

Long non-coding RNAs (lncRNA) are a type of RNA molecule that do not carry instructions to make proteins. Instead, they influence how other genes are expressed. There are tens of thousands of lncRNAs ...

Digital spatial profiling of advanced solid tumors and lymphomas from a phase 1 trial of copanlisib and nivolumab. Using single-cell sequencing to identify endothelial expression of immune checkpoint ...

While widely adopted for comprehensive transcriptome profiling, the methods of poly-A selected or ribodepleted RNA-sequencing may have key limitations, including input mass requirements, inefficient ...

In RNA molecules, the 5′ untranslated region (UTR) is located directly upstream of the start codon and plays a crucial role in post-transcriptional regulation by controlling RNA stability, cellular ...

The non-coding genome, once dismissed as "junk DNA", is now recognized as a fundamental regulator of gene expression and a key player in understanding complex diseases. Following the landmark ...