Non-coding DNA variants contribute to acute lymphoblastic leukemia (ALL) chemotherapy resistance. St. Jude Children's Research Hospital scientists have identified specific DNA variants in the ...

Scientists have identified how specific genetic changes function in cells to influence disease risk and other human health ...

A massive genomics effort has identified thousands of single nucleotide non-coding variants, which alter gene activity, that link to disease and health.

There are some genes that can promote cancer; they are sometimes called oncogenes, and in tumor cells, mutations are often found in these genes. When they are functioning normally, oncogenes are often ...

Researchers announced a significant paradigm shift in the understanding of T-lineage acute lymphoblastic leukemia (T-ALL), an aggressive and high-risk form of cancer, to one frequently driven by ...

Researchers have developed a method to swiftly screen the non-coding DNA of the human genome for links to diseases that are driven by changes in gene regulation. The technique could revolutionize ...

For decades, scientists have been puzzled by large portions of the human genome labeled as “junk” DNA, sequences that seemingly serve no purpose. Yet, recent studies suggest these cryptic sequences ...

Why cells grow to just the right size has long baffled scientists. Too small or too large, and cells can trigger serious diseases, but the genetic switch behind this balance has remained elusive. Now, ...

Researchers have revealed that so-called ‘junk DNA’ contains powerful switches that help control brain cells linked to Alzheimer’s disease. When people picture DNA, they often imagine a set of genes ...

(L to R) Co-first author Jackson Mobley, PhD, corresponding author Daniel Savic, PhD, and co-first author Kashi Raj Bhattarai, PhD, all of the St. Jude Department of Pharmacy and Pharmaceutical ...