Renal cell carcinoma (RCC) exemplifies how oncogenic mutations, notably in the von Hippel-Lindau (VHL) gene, drive profound alterations in cellular metabolism. Loss of VHL stabilises hypoxia-inducible ...
Melanoma cells exhibit pronounced metabolic plasticity that underpins their rapid proliferation, invasion and resistance to therapy. While many tumours rely on aerobic glycolysis to fulfil ...
A newly published review article highlights the critical role of fatty acid metabolism in shaping the tumor microenvironment and influencing cancer progression, offering fresh perspectives for the ...
Aerobic glycolysis dominates lesion bioenergetics, with lactate promoting histone lactylation, M2 macrophage polarization, CD8⁺ T-cell exhaustion, EMT, and fibrosis that reinforce immune-protected ...
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