Melanoma cells exhibit pronounced metabolic plasticity that underpins their rapid proliferation, invasion and resistance to therapy. While many tumours rely on aerobic glycolysis to fulfil ...
Metabolic reprogramming is a defining hallmark of breast cancer, encompassing diverse alterations in energy utilisation, biosynthetic pathways and intracellular signalling. Tumour cells frequently ...
Lactate, once considered a metabolic waste product, is now recognized as a key regulator of cellular homeostasis and disease progression. In gynecological malignancies-including ovarian, cervical, and ...
Tumor-associated macrophages (TAMs) are immune cells that tumors hijack to fuel their own growth and evade immune attack. A ...
However,instead of attacking cancer cells, they are typically co-opted to support tumor growth, metastasis, and therapeutic ...
Researchers have uncovered how metabolic reprogramming contributes to renal fibrosis in IgG4-related disease (IgG4-RD), a systemic immune-mediated disorder. The review, published in a leading journal, ...
Machine Learning–Driven Risk Stratification and Adjuvant Treatment Guidance in Oral Cavity Cancer We analyzed stage I LUAD samples from The Cancer Genome Atlas, Gene Expression Omnibus, and European ...
A recent study has demonstrated the power of metabolic engineering in enhancing the antitumor activity of chimeric antigen receptor (CAR) macrophages (CAR-Ms) in solid tumors. By overexpressing the ...
Integrating circulating tumor DNA (ctDNA) and TP53 alteration variant allele frequency (VAF) to predict outcomes in advanced urothelial carcinoma (aUC) treated with enfortumab vedotin (EV).
Aerobic glycolysis dominates lesion bioenergetics, with lactate promoting histone lactylation, M2 macrophage polarization, CD8⁺ T-cell exhaustion, EMT, and fibrosis that reinforce immune-protected ...
For the first time ever, NTNU researchers have identified new characteristics of aggressive prostate cancer. The research lays a foundation for the possibility that aggressive prostate cancer can ...
People with obesity and type 2 diabetes are at high risk of blood vessel damage. This risk depends not only on the genes a person carries, but also on how they are "read." By changing the epigenetic ...
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