Mast cells are centrally implicated in the progression of diabetic kidney disease through their roles in inflammation, fibrotic remodelling and microvascular dysfunction. In the diabetic milieu, ...

Mast cells are central effectors in asthma, acting as both initiators and amplifiers of airway inflammation. Residing in peribronchial tissues and the epithelium, they respond to immunoglobulin E (IgE ...

Cutaneous mastocytosis is one of two types of mastocytosis, a rare disorder in which too many mast cells — a type of white blood cell that helps the immune system function properly — accumulate in the ...

The activation of mast cells in the lungs and skin is involved in diseases such as asthma and chronic spontaneous urticaria, where the KIT receptor tyrosine kinase is a key regulator of mast cell ...

Scientists show that prenatal stress reshapes fetal mast cells and sensory neurons, creating a fragile skin barrier that sparks early-life eczema in mice. Study: Maternal stress triggers early-life ...