We were unable to process your request. Please try again later. If you continue to have this issue please contact customerservice@slackinc.com. Adults with a loss-of-function mutation in the MC4R gene ...

Angiopoietin-like protein 3 (ANGPTL3) inhibits lipoprotein and endothelial lipases. ANGPTL3 loss-of-function genetic variants are associated with decreased levels of low-density lipoprotein ...

In a novel study, researchers from the Icahn School of Medicine at Mount Sinai introduced LoGoFunc, an advanced computational tool that predicts pathogenic gain- and loss-of-function variants across ...

Targets primarily include PCSK9, ANGPTL3, HSD17B13, KHK, ASGR1, GPR75, CIDEB, and INHBE. Drug types primarily include small molecules, monoclonal antibodies, RNAi, and CRISPR gene editing therapies.

A genetic mutation passed from mother to children in families affected by schizophrenia has now been shown to completely ...

Korean researchers have developed a gene therapy method that accurately corrects the representative mutation (c.220C>T) of the MPZL2 gene that causes hereditary hearing loss, and succeeded in proving ...