Intrinsically disordered proteins lack a fixed structure, which is why they have been considered "undruggable" targets for ...

A DGIST research team led by Prof. Yoo Wookyung (Department of Brain Sciences) and Prof. Kim Jin Hae (Department of New Biology) developed an innovative analytical technology in collaboration with a ...

RIKEN researchers have discovered how an enzyme modifies gene expression by targeting certain stretches of messenger RNA ...

Researchers led by  Dr. Xavier Salvatella have uncovered the mechanism by which an experimental drug is able to block intrinsically disordered proteins, which were previously considered “undruggable”.

Different DNA Structures Nucleate the Folding of Proteins to form specific complexes that modulate the readout of ...

Intrinsically disordered proteins (IDPs) do not attain a stable secondary or tertiary structure and rapidly change their ...

Researchers at Harvard and Northwestern have developed a machine learning method that can design intrinsically disordered proteins with custom properties, addressing nearly 30% of all human proteins ...

In synthetic and structural biology, advances in artificial intelligence have led to an explosion of designing new proteins with specific functions, from antibodies to blood clotting agents, by using ...

Textbooks often depict proteins in one conformation, but real life, as usual, is much messier. While some proteins have stable, unchanging structures, many others have intrinsically disordered regions ...

Intrinsically disordered proteins (IDPs) make up about 30 percent of our proteome. They are important to many fundamental aspects of biology and disrupted in disease. Since they lack a stable shape, ...