Bone formation and maintenance depend on the coordinated activity of osteoblasts, osteoclasts and osteocytes, whose differentiation and function are governed by tightly regulated gene networks.

A molecule once thought to be a harmful metabolic byproduct may play a crucial role in early development and gene regulation, according to a new study published in Nature that challenges decades of ...

Precision and timing of gene expression is essential for normal biological functions and, when disrupted, can lead to many human diseases, including cancers. However, how molecular machines—protein ...

Paired box 6 (PAX6) is a member of the highly conserved paired box (PAX) transcription factors. Transcription factors regulate the activity of large numbers of genes involved in development. The PAX6 ...

Graphical summary of the study. Overweight or obese East Asian individuals underwent a 16-week lifestyle intervention involving diet and exercise. The study revealed improvements in metabolic health, ...

In 2012, The Scientist profiled molecular biologist Erica Larschan, who had not long before established her own laboratory at Brown University. Larschan’s early interest in biology led her to focus ...

Livestock breeders could soon have more tools to improve the health and quality of their animals, thanks to a recent study that sheds new light on regulatory elements in the sheep genome. Previous ...