Much of the phenotypic variation that is observed within and between species is the result of differences in gene regulation: specifically when, where and how much the genes are expressed. Given the ...

Our brain is arguably the organ that most distinguishes humans from other primates. Its exceptional size, complexity and capabilities far exceed those of any other species on Earth. Yet humans share ...

Essentially all cells in an organism's body have the same genetic blueprint, or genome, but the set of genes that are actively expressed at any given time in a cell determines what type of cell it ...

New research suggests that alternative splicing may have an even greater influence on biology than just by creating new protein isoforms. The study shows that the biggest impact of alternative ...

Single-cell analyses revealed molecular profiles that can distinguish PTSD from depression, potentially leading to better drugs for this psychiatric disorder. To test this hypothesis, Girgenti and his ...

As winter approaches, humans in the higher latitudes might beat the cold by snuggling up under a pile of blankets or booking a timeshare in sunny Florida. Similarly, some animals cope with seasonal ...

Gene expression leading to alterations in the DNA caused by asbestos exposure may explain the development of Malignant Pleural Mesothelioma (MPM), a rare and aggressive cancer. By analyzing public RNA ...

Site-specific therapy guided by gene-expressing profiling (GEP) could improve outcomes for patients with previously untreated cancers of unknown primary (CUP), Chinese researchers suggested. In their ...

A new international study suggests that ancient viral DNA embedded in our genome, which were long dismissed as genetic "junk", may actually play powerful roles in regulating gene expression. Focusing ...

Long non-coding RNAs (lncRNA) are a type of RNA molecule that do not carry instructions to make proteins. Instead, they influence how other genes are expressed. There are tens of thousands of lncRNAs ...

Single cell gene expression studies often rely on single-cell RNA sequencing (scRNA-seq) alone. While scRNA-seq reveals which genes are turned on, it does not capture protein expression or changes to ...

While the process via which different types of neurons are produced, also known as neurogenesis, has been the focus of numerous neuroscience studies, its genetic and biological underpinnings in humans ...