Over the past two decades, researchers have learned that DNA inside the cell nucleus naturally folds into a network of ...

Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal ...

Gene therapy holds the promise of preventing and curing disease by manipulating gene expression within a patient's cells. However, to be effective, the new gene must make it into a cell's nucleus. The ...

In 1869, Swiss scientist Friedrich Miescher isolated a mysterious substance from cell nuclei—an overlooked finding that would ...

If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by ...

Daniele Canzio, PhD, of the Department of Neurology and Balyn Zaro, PhD, of the Department of Pharmaceutical Chemistry have ...

Reporting in Nature, scientists have identified a novel process that protects the ends of chromosomes from incorrectly applied DNA repair. Although DNA repair is a crucial mechanism that can protect a ...

Only around two percent of the human genome codes for proteins, and while those proteins carry out many important functions of the cell, the rest of the genome cannot be ignored. However, for decades ...

Scientists manufacture many biotherapeutic products in immortalized cell lines, most commonly HEK293. Residual HEK293 DNA in biotherapeutic candidates can harbor tumorigenic or retroviral sequences ...

Using single-cell epigenomic profiling of immune cells from 110 individuals, researchers show that genetic variation and ...