Gene therapy holds the promise of preventing and curing disease by manipulating gene expression within a patient's cells.

Over the past two decades, researchers have learned that DNA inside the cell nucleus naturally folds into a network of ...

Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal ...

In 1869, Swiss scientist Friedrich Miescher isolated a mysterious substance from cell nuclei—an overlooked finding that would ...

Daniele Canzio, PhD, of the Department of Neurology and Balyn Zaro, PhD, of the Department of Pharmaceutical Chemistry have ...

If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by ...

Only around two percent of the human genome codes for proteins, and while those proteins carry out many important functions of the cell, the rest of the genome cannot be ignored. However, for decades ...

In human cells, there are about 20,000 genes on a two-meter DNA strand—finely coiled up in a nucleus about 10 micrometers in diameter. By comparison, this corresponds to a 40-kilometer thread packed ...

Scientists manufacture many biotherapeutic products in immortalized cell lines, most commonly HEK293. Residual HEK293 DNA in biotherapeutic candidates can harbor tumorigenic or retroviral sequences ...

Using single-cell epigenomic profiling of immune cells from 110 individuals, researchers show that genetic variation and ...