Carolyn Bertozzi of Stanford University, Morten Meldal of the University of Copenhagen, and K. Barry Sharpless of Scripps Research won the Nobel Prize in chemistry on Wednesday “for the development of ...

Scientists have illuminated the mechanism at the heart of one of the most useful processes in modern chemistry. A reaction that is robust and easy to perform, it is widely employed to synthesize new ...

Carolyn Bertozzi, Morten Meldal and K. Barry Sharpless have been awarded the 2022 Nobel Prize in Chemistry for the development of click chemistry and bioorthogonal chemistry. Click chemistry ...

The proposed platform for triple click chemistry has three functional groups that can be independently targeted for replacement by choosing an appropriate reaction partner. This platform is compatible ...

Increasing our understanding of cellular processes requires information about the types of biomolecules involved, their locations, and their interactions. This requires the molecules to be labeled ...

A fast new light-activated reaction enables a way to visualize rapidly unfolding molecular events and interactions in live cells in real time (J. Am. Chem. Soc. 2022, DOI: 10.1021/jacs.1c10390). The ...

A major challenge in the development of novel therapeutics is the precise localization and activation of drugs to specific areas in the body. Twenty years ago ‘click chemistry’, a simple yet powerful ...

Triple click chemistry has revolutionized chemical synthesis with its simplicity and efficiency, allowing for the quick and selective assembly of complex molecules. Now, in a recent study, researchers ...

It has been almost a quarter-century since K. Barry Sharpless, M.G. Finn, and Hartmuth C. Kolb published the paper that some refer to as the click manifesto. In it, the researchers presented a vision ...

Organosulfur(VI) fluoride compounds display excellent chemical stability, and yet can efficiently realize diverse linkages via the activation of specific conditions. Based on its unique nature, ...

An emerging paradigm in organic synthesis is a focus on highly selective and orthogonal reactions that proceed with high efficiency and under a variety of mild conditions. A growing number of these ...