Gene regulation and chromatin dynamics constitute central themes in modern molecular biology, governing how the genetic blueprint is accessed and utilised during development, differentiation and ...
As many as 1 in 4 cancers are driven by mutations in the SWI/SNF chromatin-remodeling complex, which controls access to DNA. A study led by St. Jude Children's Research Hospital recently identified ...
This study is led by Professor Zhenhui Zhong (College of Life Sciences, Sichuan University, Chengdu, China). The authors investigated global chromatin states and gene expression levels in soybean. The ...
New research led by Professor Yogesh Dwivedi at the University of Alabama at Birmingham uncovers how long noncoding RNAs engage chromatin-silencing machinery under glucocorticoid receptor activation, ...
What if the brain's response to stress could be read not in fleeting neurotransmitter bursts, but in the quieting of genes deep inside chromatin? Researchers at the University of Alabama at Birmingham ...
Every cell type in the human body carries the same approximately 3.2 billion base pairs of DNA, yet a liver cell behaves nothing like a neuron. The epigenome explains this difference: in each cell, ...
Genomic DNA is organized into chromatin via nucleosomes, regulating its accessibility for critical biological processes such as transcription, replication, and epigenetic modification. The dynamic ...
Defining the mechanistic interface between post-transcriptional RNA regulation and chromatin regulation that controls transcriptional and epigenetic programs underlying stem cell maintenance, cellular ...
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Cracking the code of gene regulation
From DNA’s tightly packed chromatin to the precise on/off switches in regulatory sequences, scientists are uncovering how cells fine-tune gene expression. New research reveals surprising roles for ...
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