Background Patients with severe aortic stenosis (AS) are at high risk of mortality, regardless of symptom status. Despite ...

Bicuspid aortic valve (BAV), the most common heart valve birth defect, is associated with genetic variation in human primary cilia during heart valve development, report researchers. Crucial to cilia ...

Unexpected role for HAND2 transcription factor in cardiac valve formation A research team led by Prof. Zeller and Dr. Zuniga from the University of Basel has identified the so-called HAND2 gene as a ...

Mitral valve prolapse (MVP) is a common congenital abnormality of the heart that can cause severe complications such as arrhythmias, heart failure, and sudden cardiac death. To date, the causes of MVP ...

Mechanisms of heart-valve disease often mimic processes observed in embryonic and early childhood development, including activation of valvular interstitial cell (VIC) phenotypes and remodeling of ...

Genetic mutations in heart valve cells of the developing fetus lead to mitral valve prolapse, report a global collaborative of researchers. These mutations or genetic variations cause defects in ...

A global research collaborative including Medical University of South Carolina investigators report in today's Science Translational Medicine that defects in the primary cilia of the developing fetus ...