In recent months, the Food and Drug Administration and National Institutes of Health have announced new initiatives to reduce and replace animal testing in biomedical research. Central to these ...

Animal studies often fail to predict human tissue responses to new drugs or newly developed therapies. Besides generating ...

Every year, more than 100 million animals are used globally in biomedical research, yet over 90% of drugs that appear effective in animal trials fail during human clinical testing. 1 This staggering ...

Animal models are established, important tools for preclinical safety and efficacy testing. Companies are advancing more “humanized” models to better reflect human responses, while at the same time ...

Animal models continue to be a mainstay of basic research and preclinical studies. But since animals such as mice only approximate humans, they may generate findings of limited clinical relevance.