As a person’s symptoms of Alzheimer’s disease emerge and worsen, tau tangles spread inexorably through the cortex. What unfortunate series of events pushes this microtubule-binding protein into a ...

Protein aggregation in certain tissues is a hallmark of diseases such as neurodegeneration and occurs during ageing, but little is known about how protein quality control mechanisms acting to prevent ...

Protein-based therapeutics have transformed treatments for numerous diseases, yet their production remains highly complex and cost-intensive [1][2],[3][4]. Downstream processing (DSP), including ...

Recent research suggests that people with neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS), exhibit changes in the bacterial ...

Because protein aggregation occurs in all age-related neurodegenerative diseases, understanding protein homeostasis inside neurons is a priority. Research into the cellular proteostasis network has ...